Intralymphatic immunization enhances DNA vaccination
نویسندگان
چکیده
منابع مشابه
Intralymphatic immunization enhances DNA vaccination.
Although DNA vaccines have been shown to elicit potent immune responses in animal models, initial clinical trials in humans have been disappointing, highlighting a need to optimize their immunogenicity. Naked DNA vaccines are usually administered either i.m. or intradermally. The current study shows that immunization with naked DNA by direct injection into a peripheral lymph node enhances immun...
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Vaccines are typically injected subcutaneously or intramuscularly for stimulation of immune responses. The success of this requires efficient drainage of vaccine to lymph nodes where antigen presenting cells can interact with lymphocytes for generation of the wanted immune responses. The strength and the type of immune responses induced also depend on the density or frequency of interactions as...
متن کاملdna immunization as an efficient strategy for vaccination
the field of vaccinology provides excellent promises to control different infectious and non-infectious diseases. genetic immunization as a new tool in this area by using naked dna has been shown to induce humoral as well as cellular immune responses with high efficiency. this demonstrates the enormous potential of this strategy for vaccination purposes. dna vaccines have been widely used to de...
متن کاملDNA Immunization as an Efficient Strategy for Vaccination
The field of vaccinology provides excellent promises to control different infectious and non-infectious diseases. Genetic immunization as a new tool in this area by using naked DNA has been shown to induce humoral as well as cellular immune responses with high efficiency. This demonstrates the enormous potential of this strategy for vaccination purposes. DNA vaccines have been widely used to de...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2001
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.051630798